IJARP SJIF(2018): 4.908

International Journal of Advanced Research and Publications!

Vitamin E, Liver And Kidney Functions Of Rabbit During Hypothermia

Volume 4 - Issue 5, May 2020 Edition
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Author(s)
Ntinya C. Johnson , Moses Diri
Keywords
Vitamin E, liver and kidney functions, hypothermia and rabbit
Abstract
Effects of oral vitamin E supplementation on the health statuses of liver and kidney of rabbits during hypothermia were studied. 24 male New Zealand White rabbits of 8 – 10 weeks old and weighed about 800 – 1000g were used in the study. The rabbits were randomly assigned to three treatment groups as: T1 (control), T2 (hypothermia) and T3 (hypothermia + vitamin E). Experimental duration was 6 weeks. Animals were fed similar diets throughout the experimental period except that T3 animals received oral vitamin E daily at 460mg/kg body weight in the last 4 days of study. 24 hours after the last administration of vitamin E T1 rabbits were dipped into water of body temperature (370C) whereas T2 and T3 rabbits were dipped into water of 10 - 120C with their heads up for 5-minutes after which their blood samples were immediately collected and snap frozen. Body temperatures of the animals after dipping were T1 (37.9 ± 0.5), T2 (34 ± 1.0) and T3 (34.2 ± 0.7), respectively. Alanine amino transferase (ALT) serum concentrations were similar (P > 0.05) for T1 and T3 but T2 had significant higher (P < 0.05) ALT. Aspartic amino transferase (AST) was significantly higher (P < 0.05) in T2 compared with T1 and T3 that had similar (P > 0.0) AST values. Alkaline phosphatase (ALP) serum concentration was significantly different (P < 0.05) for T1, T2 and T3 with T2 showing the highest concentration. Blood urea nitrogen (BUN) levels were similar (P > 0.05) in T1 and T3 while T2 had a significant higher (P < 0.05) BUN value. Creatinine levels were similar (P > 0.05) in T1 and T3 while T2 had a significant (P < 0.05) higher value. It was concluded that vitamin E supplementation can up-regulate liver and kidney functions in rabbits during hypothermic condition.
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