Paper Details: A Novel Synthesis Of Fused Pyrazolopyrimidine: Pyrazolo-Triazolo-Pyrimidine For Anticancer Evalution.
Volume 3 - Issue 8, August 2019 Edition
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A.Y. Hassan, Mona. S. Kadh, N.M. Saleh, E.S. Abou-Amra.
pyrazolo [3,4-d] pyrimidine,pyrazolotriazolopyrimidine,anticanceractivity.
Some novel fused pyrazolo-triazolo-pyrimidine (2- 5)were designed and prepared via reaction of 5-amino-6-hydrazineyl-1-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (1) with some electrophilic and nucleophilic reagents. The structures of target compounds were confirmed by elemental analyses and spectral data. The newly synthesized compounds were selected by the NCI – Maryland-U.S.A. and were tested for their anticancer activity in an initial single high dose in the full NCI 60 cell line panel.
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