IJARP SJIF(2018): 4.908

International Journal of Advanced Research and Publications!

Synthesis And Anticancer Evaluation Of Some Novel Fused Pyrazolopyrimidine Derivatives.

Volume 3 - Issue 8, August 2019 Edition
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A.Y. Hassan, N.M. Saleh, Mona. S. Kadh, E.S. Abou-Amra
anticancer activity, pyrazolopyrimidopyrimidine, pyrazolopyridopyrimidine.
A new pyrazolopyrimidine formimidate 2b, pyrazolopyrimidopyrimidine (3b, 4b, 5a), pyrazolopyrimidine formamide 6b and pyrazolopyridopyrimidine 7b derivatives were designed and prepared via reaction of substituted pyrazolo[1,5-a] pyrimidine-6-carbonitrile (1a, b) with triethyl orthoformate, formamide, urea, formic and malononitrile in different conditions. The structures of target compounds were confirmed by elemental analyses and spectral data. Four of the newly synthesized compounds were selected by the NCI – Maryland-U.S.A. and were tested for their anticancer activity in an initial single high dose in the full NCI 60 cell line panel.
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