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Laxative Potential Of Aqueous Extract Of The Aerial Parts Of Euphorbia Heterophylla In Loperamide-Induced Constipated Wistar Albino Rats

Volume 4 - Issue 1, January 2020 Edition
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Wellington, E.O, Peters, D.E, Onyeike, E.N
Euphorbia heterophylla, loperamide, constipation, laxatives, faecal properties, electrolytes, wistar rats, gastrointestinal motility, intestinal fluid, biochemical assays
Background and Objectives: Euphorbia heterophylla is a medicinal plant that is known to elicit several medicinal properties such anti-malaria, anti-anaemic, treatment of asthma and many other health problems. This study investigated the laxative potential of aqueous extract of the aerial parts of E heterophylla in constipated wistar rats. Materials and Methods: Constipation was induced by oral administration of 1ml of 3mg/kg body weight of loperamide for three days and the passage of dry and reduced number of faecal pellet was indicative of the episode of constipation in the rats. Results: The faecal properties such as number of faecal pellet, faecal, faecal water content and gastrointestinal motility were determine following the “Cho’’ method of determination faecal properties in condition of constipation. Plasma electrolytes (Na+, K+, Cl-, Ca2+ and Mg+) and urea concentrations were determined using colorimetric method. Significant increases (p≤0.05) were observed in the number of faecal pellet (171.29± 30.13), weight of faecal pellet (38.69± 2.92g) and faecal water content (2.01±0.12ml) in 1500mg/kg b.w treated group when compared to their respective control values. Gastrointestinal motility significantly increased (p≤0.05) for 1500mgkg b.w treated group (94.23%) in comparison to the constipated control (73.45%). Significant increase (p≤0.05) in concentrations of plasma sodium (Na+), potassium (K+), chloride (Cl-), magnesium (Mg2+), calcium (Ca2+) and urea (147.20 ± 1.48, 4.35± 0.09, 133.20 ± 2.05, 2.19 ± 0.01, 2.71 ± 0.01, and 9.25 ± 0.03 respectively) were observed for 1500mg/kg b.w treatment in comparison to the control values. Conclusion: The significant increases in the number of faecal pellet, weight of faecal pellet, faecal water content, gastrointestinal motility and the plasma electrolyte concentrations is indicative that aqueous extract of the aerial parts of Euphorbia heterophylla elicited laxative potential against constipation induction.
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