SJIF(2020): 5.702

International Journal of Advanced Research and Publications

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Isolation And Antibiogram Profile Of Multiple Drugs Resistance Pseudomonas Aeruginosa From Burn Wound Infection In Western Nepal

Volume 4 - Issue 1, January 2020 Edition
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Ram Bahadur Khadka, Balram Neupane, Bikram Khadka, Manoj Kafle
Antibiotic Susceptibility, Burn Infection, Multi Drug Resistance, Pseudomonas aeruginosa,
Different microorganisms that resist multiple antibiotics is considered to be most threatening problems to public health now a days. The aim of this study was to evaluate antibiotic resistance of Pseudomonas aeruginosa in burn wound infection and the antibiotic susceptibility pattern of P. aeruginosa isolates.Wound pus was collected using a sterile swab from all age group excluding the patients already on antibiotic therapy. One hundred eighty four (184) samples were collected from the wound pus in Medicross Diagnositc Center, Butwal, Nepal from October , 2017 through March , 2018.Out of 184 samples, 48 Pseudomonas aeruginosa strains were isolated and tested for antibiotic susceptibility against different antibiotics. The pattern of antibiotic susceptibility suggested that 100% of the isolates were resistant to Tobramycin, and 94.1% were resistance to Cefoperazone and Meropenem whereas the least resistance was shown against ciprofloxacin (35.3%) followed by amikacin and gentamicin (47.1%) both. The percentage of multi drug resistance in Pseudomonas aeruginosa isolates was 100% since all these positive samples were resistant to at least 3 drugs in the following classes: β-lactams, carbapenems, aminoglycosides and fluoroquinolones. In P. aeruginosa infections, periodic antimicrobial resistance monitoring is fundamental to update the current activity level of commonly used anti-pseudomonal drugs to minimize the risk of drug resistance.
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